4-chlorophenoxy acetic acid (2) was prepared by condensation of phenol with monochloroacetic acid. Compound (2) was refluxed with ethanol in the presence of HCL gas yielding ethyl (4-chlorophenoxy) acetate (3). Compound (3) was refluxed hydrazine hydrate in ethanol which produced 2-(4-chlorophenoxy) acetohydrazide (4). Schiff bases were synthesized by the reaction of substituted aldehydes with 2-(4-chlorophenoxy) acetohydrazide (4) in presence of ethanol. These Schiff bases on reaction with acetic anhydride gave the corresponding 3-acetyl-2,3-dihydro 1,3,4-oxadiazole (5a & 5b).synthesized compounds were characterized on the basis of TLC monitoring , melting point, spectral and analytical data. All the compounds screened for antimicrobial and antifungal activity.
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